Daily oral PrEP with Truvada®

Daily oral PrEP


  • Use once every day.
  • Sex without planning.
  • Daily pill. Large pill size.

A pill you take once a day to prevent HIV.

If you take the pill every day, it works extremely well. It’s greater than 99% effective when used daily.

Absolutely anyone.

Every day. Once a day.

You can remember to take the pill every day.

Sort of. It’s not advised to miss a dose, but things happen and missing a dose here and there is okay.

The latest data suggest that cis-men and trans women have 99% protection with 4 doses/week. Cis-women have 88% protection with 4 doses/week. We don’t have data for trans men.

There are a few side effects.

Headaches, abdominal pain, and weight loss are common but go away after a couple of weeks. Kidney problems and bone density loss can happen but are rare.

No need to plan sex around pill taking.

Truvada® is available as a generic medication, which may be less expensive for you.

It will depend on your insurance. Without insurance or patient assistance programs, it costs about $40/month.

The generic version can be the least expensive PrEP choice.

If you already have a strong daily vitamin or medicine routine, you can add Truvada® to it.

If you decide to switch to an on-demand strategy you won’t need a new prescription.

Truvada® has also been shown to be slightly better for cholesterol and weight than daily oral PrEP with Descovy®.

Alcohol and other drugs do not affect PrEP.  Learn more.

It’s a daily pill. To say protected, you can’t forget it a lot.

The pill size is also on the larger size.

As a daily pill, it can be the less private option compared to a shot.

Truvada® doesn’t affect hormone levels. Generally, hormones don’t affect how well PrEP works.

Estradiol may reduce PrEP levels slightly. So, if you’re taking estradiol, take Truvada® with food.

Truvada® stops HIV from reproducing. So, it can’t infect you.

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